Past Talk Recordings

Quantum sensing the brain: next generation neuroimaging using optically pumped magnetometers

Abstract: The field of magnetoencephalography (MEG) has been revolutionised in recent years by the introduction of optically pumped magnetometers (OPMs). These “Lego-brick-sized” sensors can measure magnetic fields generated by the human brain, without the need for cryogenic cooling (as is the case for conventional SQUID-based MEG instrumentation). This offers significant advantages both in terms of system performance (sensitivity and spatial resolution) and practicality (to scan infants or undertake novel experimental paradigms). In this talk, I will describe our experiences of OPMs in Nottingham, throughout a decade of research developing and deploying OPM-MEG. I will show how systems have expanded from a single-channel instrument, to our most recent 384-channel measurements; I will demonstrate how high fidelity magnetic field control has enabled free movement during scanning, and how this has led to new types of naturalistic experiment; I will explain how OPMs enable better sensitivity and show data on how high density arrays outperform SQUIDs. Finally, I will show our most recent data, where our OPM-MEG device has been used to explore neurodevelopment in children as young as two years old.

Bio: Matt Brookes is a Professor of Physics at the Sir Peter Mansfield Imaging Centre, University of Nottingham, UK. His work centres on development and application of multi-modal brain imaging, particularly MEG where over the last 20 years his group has made significant contributions to inverse modelling, connectivity measurement, clinical applications and development of MEG hardware using OPMs. Brookes was the recipient of a Blavatnik Laureate award in physical sciences and engineering in 2022, and an OBE for services to physics in 2024.

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Alteration in predictive language processing in different stages of psychosis

Abstract: Alterations in speech represent a core symptom of schizophrenia, the underlying mechanisms and links to positive and negative symptoms are still limited. Here, I am using the predictive coding framework to investigate how predictive language alterations link to positive symptoms. Specifically, I am interested in exploring how an imbalanced weighting of prior knowledge and sensory evidence links to hallucinations and delusions. We developed a novel predictive language task which reflects Bayesian inferential processing. Additionally, we set up a Bayesian belief updating model which allows us to extract and simulate the prior weight during language perception, informing us whether individuals rely more on prior knowledge or more on sensory evidence when listening to speech. I will present results from a healthy cohort with schizotypy scores and schizophrenia patients first in acute psychosis and then in psychotic remission. In both cohorts, I will be able to show a link between an overweighting of high-level priors and positive symptoms. Additional, I will link the results to EEG and spectroscopy data.

Bio: Franziska Knolle is a research group leader (since 2022) at the Department of Neuroradiology at the Technical University of Munich, in Germany, and former Marie Skłodowska-Curie Fellow (2020). She did her PhD at the Max-Planck-Institute of Human Cognitive and Brain Science in Leipzig in 2012. After a break from academia during which she studied Human Medicine, she conducted two postdocs at the Department of Physiology, Development and Neuroscience, and the Department of Psychiatry at the University of Cambridge from 2016-2019.

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Abstract: Delirium is a neurocognitive disorder characterised by acute and fluctuating impairments in cognition and arousal. It can occur at any age but is most common in late-life. It is precipitated by an acute insult such as surgery, and varies in its presentation, severity, and duration. It is associated with a range of poor outcomes in older adults including incident dementia and institutionalisation. Delirium is arguably the most interesting and understudied disorder in the field of cognitive neuroscience. I will cover our previous work investigating the clinical characteristics, neuropsychology, and neurophysiology of delirium. I’ll also introduce two new studies: (i) DelIrium VULnerability in GEriatrics (DIVULGE) 2 assessing EEG in the context of delirium, and (ii) the Help After Leaving hospiTal (HALT) Trial, a co-designed multidisciplinary and tailored intervention study to prevent decline after in-hospital delirium.

Bio: I am a Professor of Psychology at the University of South Australia. My work focuses on cognitive ageing and cognitive impairments, such as dementia and delirium, using neuropsychological and psychophysiological approaches. Between 2007 and 2011 I undertook post-doctoral positions at the University of Cambridge, working on longitudinal cohort studies of ageing and dementia with brain donation programs, with Professor Carol Brayne. In 2011 I returned to Australia, taking up an academic position in psychology at the University of South Australia. I am a past-President of the Australasian Cognitive Neuroscience Society, a member of the Australian Academy of Sciences Committee for the Brain and Mind and co-lead the Cognitive Ageing and Impairment Neurosciences Lab (@CAIN_Lab).

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Abstract: This talk outlines unique challenges facing OPMs in terms of interference; demonstrate that OPMs can measure neural activity during movement; and introduce our setup combining OPMs and virtual reality to study the encoding and retrieval of autobiographical memories.

Bio: Dr. Robert Seymour is a Research Fellow at University College London. His research uses magnetoencephalography to answer fundamental questions across cognitive and clinical neuroscience. His PhD used conventional SQUID-MEG to study brain connectivity during visual processing in autism spectrum disorder. During his postdoctoral research at UCL he has developed wearable MEG with the goal of conducting more naturalistic neuroimaging experiments involving movement. In the future, Rob aims to use wearable MEG to advance our understanding of natural social interactions, including in neurodiverse populations.

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Abstract: Spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals correlate across distant brain areas, forming functional subsystems that appear disrupted in numerous psychiatric and neurological disorders, pointing to a key role in brain function. However, the generative mechanism of fMRI signal correlations are not fully understood. In this talk, I will give an overview of the evidence gathered applying Leading Eigenvector Dynamics Analysis (LEiDA) on different neuroimaging datasets and the insights it provides to understand brain function. I will further show recent insights from rat experiments supporting the view that functional networks are linked with the universal principle of Resonance, understanding the organizing principles of functional networks is crucial to develop efficient strategies targeting long-range interactions between brain areas.

Bio: Joana Cabral is a Biomedical Engineer interested in deciphering mechanisms of brain function. She did her PhD in Computational Neuroscience with Gustavo Deco, Spain, followed by a postdoc at the Psychiatry department in Oxford, UK, with Morten Kringelbach. She returned to Portugal in 2017, where she maintains an extensive network of international collaborations. She has published over 60 research articles covering a wide range of neuroimaging studies and modelling works and has presented in over 40 international meetings. She was awarded the L’Oréal award for Women in Science in 2018 and is currently funded by Fundación La Caixa.

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Abstract: Traditionally, the function of the lateral hypothalamus has been restricted to feeding and promoting other innate behaviours that promote homeostasis. However, we have recently demonstrated that this region is critical for reinforcement learning. Specifically, using the temporal specificity of optogenetics, we demonstrated that the lateral hypothalamus is critical for using cues in the environment to predict arrival of food, over and above a role in feeding. Surprisingly, our subsequent studies revealed that the lateral hypothalamus actively opposes learning about cues that are distal or irrelevant to predicting food. Together, this has led to our new theory that the lateral hypothalamus is a critical arbitrator of reinforcement learning, which prioritizes learning and behaviour directed towards important events (e.g. food or pain). In this talk, I will discuss the data that led to this theory and the implications this has for how we view the contribution of the lateral hypothalamus to psychological disorders, like addiction and schizophrenia.

Bio: Dr. Melissa Sharpe holds a Ph.D. in Psychology (UNSW). Dr. Sharpe received postdoctoral research training in the United States at National Institute on Drug Abuse (NIDA) and Princeton University, which was supported by an NHMRC CJ Martin Biomedical Fellowship. Dr. Melissa Sharpe began her lab in the Department of Psychology at UCLA in 2018, receiving the US National Science Foundation (NSF) CAREER Award fellowship in 2022. Dr Sharpe recently moved her research group to the University of Sydney. The lab investigates the neural circuits involved in reinforcement learning using a modern suite of neuroscience techniques including optogenetics and fiber photometry of genetically encoded activity sensors (e.g. calcium, dopamine, serotonin). The lab is funded by the US National Institutes of Health, including the National Institute on Mental Health and National Institute on Drug Abuse.

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Abstract: Boredom has been cast as a call to action, a self-regulatory signal prompting us to explore our environs for something more meaningful or purposeful to engage with. This casts the trait propensity to experience boredom frequently and intensely – so-called boredom proneness – as a conundrum; the recognition of the need for something meaningful to engage with, coupled with the failure to launch into action. I will present data from neuroimaging (fMRI, EEG) work and individual differences studies to show that boredom proneness can be cast as both a disengaged attentional state and a struggle to establish a sense of agency. In addition, I will show some recent work from our lab exploring the role of interoceptive awareness in boredom proneness. This work suggests that the highly boredom prone are hyper-aware of internal states but confused by them. This confluence may underlie the felt challenge to agency that is characteristic of boredom.

Bio: James Danckert was trained as a Clinical Neuropsychologist in Australia before moving to Canada to do postdoctoral research in Cognitive Neuroscience at the University of Western Ontario in 1999 under the guidance of Mel Goodale. He was awarded a Tier II Canada Research Chair in Cognitive Neuroscience at the University of Waterloo in 2002 where he is currently a Professor in the Psychology Department. He maintains two research programs. The first explores the neural and cognitive bases of boredom and boredom proneness. The second examines the neural networks involved in building and updating mental models of the world. James’ lab makes use of behavioural studies, neuroimaging techniques (fMRI, EEG) and work in patients with neurological injuries. He has authored over 100 journal articles and book chapters and is co-author, with John Eastwood, of the book Out of my skull: The psychology of boredom.

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Abstract: This talk will delve into the nature of voluntary action, presenting recent research findings that investigate the brain activity preceding voluntary actions. The traditional unitary concept of voluntary action will be challenged, suggesting a transformative shift in the concept of voluntary action, evolving from a singular, unified notion to the recognition of its multifaceted nature. It will emphasise the need to explore not only the 'what' and 'when' of voluntary actions but also the often-overlooked 'why' that drives them. Furthermore, it will introduce the conscious experience of acting that accompanies the execution of voluntary actions, delving into the relationship between premotor brain activity and our so-called “sense of agency”.

Bio: Dr Silvia Seghezzi is a postdoctoral research fellow at the University College London (UCL). Her research investigates the neural bases of voluntary action, and the brain processes that allow us to experience a sense of agency over external events that we control through our voluntary actions. She earned her PhD in Neuroscience from the University of Milano-Bicocca and University College London (UCL) (2018-2021). After the PhD, she joined the UCL Institute of Cognitive Neuroscience as a postdoctoral research fellow in Prof. Patrick Haggard’s group. Her postdoctoral work has been supported by personal Postdoctoral Fellowships by the John Templeton Foundation (2021-2022) and the Experimental Psychology Society (2022-2023). From January 2024, she will be joining Birkbeck University of London as a Lecturer.

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Abstract: Perceptual decision-making is a fundamental cognitive process that enables us to form judgments based on sensory information. The neural mechanisms underpinning perceptual decision-making have been extensively studied using various techniques, including behaviour, electrophysiology, and brain imaging. This body of research broadly suggests two significant components: the brain's representation of sensory evidence, and the integration of sensory evidence (or evidence accumulation) through higher-order decision processes. Much of the literature has concentrated on the latter, with the aim of comprehending higher-order decision mechanisms. Nevertheless, the sensory evidence is equally crucial, as higher-order decision processes depend on this information to make informed choices, potentially affecting late-stage decision-making processes. In this talk, I will discuss our prior work investigating the role of perceptual evidence in decision-making. In addition, I will discuss ongoing research from our laboratory that explores the role of visual perception in food-related decision-making behaviour. Collectively, this body of work underscores the significance of perception in decision-making and demonstrates how these findings can be expanded to enhance our understanding of behaviour relevant to society.

Bio: Dr. Thomas Carlson is a cognitive neuroscientist whose work has focused on the neural foundations of object perception, attention, and consciousness. In addition, he has been a pioneer in the development of multivariate pattern analysis methods (commonly known as neural decoding) for fMRI and M/EEG. He completed his undergraduate and PhD studies at the University of Minnesota. After a postdoc in the Harvard Vision Science Lab, he assumed his first academic position as an Assistant Professor at the University of Maryland in 2008. In 2013, he relocated to Macquarie University and then to the University of Sydney in 2016. In 2022, he was promoted to Professor of Computational Cognitive Neuroscience in the School of Psychology at the University of Sydney. He is a former ARC Future Fellow and a past president of the Australasian Cognitive Neuroscience Society.

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Abstract: A debate exists whether it is possible to prevent attentional capture by salient singletons that automatically generate priority signals. Stimulus-driven capture, goal-dependent contingent capture and hybrid models, such as the signal suppression hypothesis of controlled attention capture, have been put forward to try solving the controversy on how salient-but-irrelevant features guide visual search through the phenomenon of attentional capture. With the current study, we tested the hypothesis whether increasing task demands with Visual Working Memory (VWM) load enhances top-down proactive feature-based control to avoid attention to be captured by salient singletons. Thirty-nine participants performed a modified delayed-match-to-sample task where a salient, yet task-irrelevant, singleton object was interleaved in-between a sample array of one to four abstract shapes to encode in VWM and the target abstract shape during the retention interval. The salient feature singleton was part of a distractor array with a high set size of 16 items and designed to induce the singleton detection mode. Using a block design, the singleton distractor object was either part of the current task set, being a same or different abstract shape as compared to incoming target, or not part of the task set, being a Chinese character. Also, these singletons were lateralised and could appear unpredictably either in the same or different visual field as compared to incoming lateralised target location. Participants were instructed to fixate a central fixation and ignore the distractor array while performing the delayed match-to-sample task. Attentional capture by the singleton objects was primarily evaluated in terms of event-related potential (ERP) components as markers of attentional selection and the extent to which distractor array is processed in memory. Electrophysiological results revealed that the magnitude of early lateralised Pd component, a neural index of proactive inhibition of feature gain, was constant across the VWM load conditions. Also, a gradual reduction of amplitude of P1, N1, anterior P2, N2pc and P3b components was observed with VWM capacity load, indicating top-down feature suppression of salient singletons. Crucially, the reduced magnitude of N2pc indicated a gradual depletion, but not elimination, of attentional capture towards the peripheral singletons with increased VWM load. Moreover, the anterior N2 showed an opposite enhanced amplitude at higher VWM load, suggesting an increased top-down cognitive control and detection of conflicting singleton features with the perceptual template of sample array stored in VWM. Lastly, the decreased P3b peak amplitude with VWM capacity load demonstrated that when VWM was strained, there was an enhanced top-down cognitive control with greater reactive suppression for to-be-ignored peripheral stimuli along with disengagement and hyperfocusing of spatial attention to the central fixation, the most parsimonious location waiting for the incoming unpredictable lateralised target to appear. The ERP results of this study shed new light into the attentional capture debate. In particular, the early Pd, P1, N1 and anterior P2 components showed that proactive inhibition of feature gain of peripheral singletons took place as predicted by the signal suppression hypothesis. However, the N2pc and anterior N2 results revealed that top-down proactive control was not strong enough to prevent attentional capture and the detection of conflicting features of these salient stimuli, including Chinese characters which were not part of the current task set. Consequently, the stimulus-driven hypothesis has demonstrated to have a stronger predictive capacity, as compared to the contingent capture and signal suppression hypotheses, in explaining the results of this study. Hence, salient, yet task-irrelevant, singleton objects always attract attention if part of a large distractor array, irrespective of current selection intentions.

Bio: Giorgio Fuggetta obtained his BSc and MSc in Psychology from University of Padua, Italy (2000), and received his Ph.D. in Neuroscience from the University of Verona, Italy (2006). He was a postdoctoral research fellow at the Institute of Cognitive Neuroscience (ICN), University College London (UCL), UK (2006-2007), and then a Lecturer in Psychology at the University of Leicester, UK (2007-2016), before being appointed to the University of Roehampton, London, UK in 2016 as a Senior Lecturer in Psychology. His current research explores the neural mechanisms underlying visual working memory and attentional control processes using electroencephalography (EEG) and Transcranial Magnetic stimulation (TMS) techniques. He is also conducting translational research in cognitive and educational psychology, studying the association between individual differences in executive function (EF) skills and academic achievement in adolescence. I teach techniques in cognitive neuroscience to MSc Applied Cognitive Neuroscience students and research methods, statistics and neuropsychology to BSc Psychology students.

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Abstract: The overarching goal of my research is to understand how we recognise different visual objects in the environment, with a specific focus on the recognition of socially relevant signals. Our remarkable ability to “read the room” is a form of social intelligence that emerges during infancy and contributes to our social wellbeing, yet its neural basis is only partially understood. How do know when a stranger is looking directly at us from across the street? How do we track changes in someone’s mood during a conversation (and can we do this efficiently via zoom)? How do we (can we) ignore social cues during criminal proceedings? To address these questions and others, I combine psychophysics with state-of-the-art neuroscientific methods (including whole brain functional imaging, single-cell recordings and inactivation techniques) and I test multiple species, including humans and rhesus macaques. In this RoundTable discussion, I will describe recent empirical work investigating (1) the neural correlates of face pareidolia and other unusual faces, (2) the link between perception of naturalistic, spontaneous facial expressions and brain activity and (3) the difference between interaction and observation modes in the primate brain. This work sets the stage for future experiments that will help us understand how, as social primates, we are able to communicate and coordinate with other social agents.

Bio: Jess Taubert was awarded her PhD in Psychology from the University of Sydney in 2009. Her first postdoctoral position was in the laboratory of Lisa Parr (Emory University, USA) where she spent her days comparing the behavioral responses of chimpanzees and rhesus macaques and trying to understand how our closest living primate relatives recognize faces. In 2011, she accepted a fellowship to move to Belgium (KU Leuven) and record single unit responses in fMRI-defined regions of the macaque brain (supervised by Rufin Vogels, Wim Vanduffel, and Bruno Rossion). Later, Jess found her way back to the University of Sydney to work with David Alais and Frans Verstraten. During this time she drove investigations about temporal effects in perceptual judgements about faces (and wrote papers about the dangers of online dating platforms like Tinder). Then in 2016, Jess took a position as a senior research fellow in the laboratory of Brain and Cognition, headed by Leslie Ungerleider (NIMH, USA). At NIMH Jess studied the brain mechanisms underlying the detection of illusory faces in primates. In 2020 she was awarded the ARC Future Fellowship and moved to the University of Queensland in August 2021 where her lab is busy trying to understand the processes underlying human social intelligence and their dysfunction. Fun fact: Jess’ first experiments investigating face perception during her honours year, compared human behavior with the behavior of domestic chickens.

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Abstract: Accurate decisions tend to be both confident and fast. Nonetheless, there are relatively few models that can simultaneously address this three-way relationship, especially for single stage decisions where participants indicate both their choice and their confidence. Extending on a common decision architecture of the linear ballistic accumulator framework, two models have been proposed – 1) a Multiple Threshold Race model which instantiates the Balance-of-Evidence hypothesis where confidence is determined through the difference between accumulated evidence for competing options (e.g., Reynolds, Osth, Kvam, & Heathcote, in revision), and 2) a newly developed Confidence Accumulator model which assumes that confidence itself is accumulated independently for each confidence option. To test these two confidence architectures, we ran two experiments manipulating the length of the confidence rating scale across 2-, 4-, or 6-options in a recognition memory task along with a perceptual task. Different models were compared that made different allowance for how the length of the confidence scale affected model parameters. While both model classes found that thresholds were affected by the length of the scale, drift rates were only minimally affected. Implications for models of confidence and response time will be discussed.

Bio: Haomin Chen graduated from the University of Melbourne with a B.A. majoring in Psychology in 2019, and obtained a 1st Class Honours in Psychology in 2020. Haomin is currently a 3rd year PhD student working under the supervision of Dr. Adam Osth in the Melbourne School of Psychological Sciences at the University of Melbourne. Her research is focused on investigating the three-way relationship between confidence, response latency and accuracy using a decision model.

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Abstract: Numerous studies have found that the Bayesian framework, which formulates the optimal integration of the knowledge of the world (i.e. prior) and current sensory evidence (i.e. likelihood), captures human behaviours sufficiently well. However, there are debates regarding whether humans use precise but cognitively demanding Bayesian computations for behaviours. Across two studies, we trained participants to estimate hidden locations of a target drawn from priors with different levels of uncertainty. In each trial, scattered dots provided noisy likelihood information about the target location. Participants showed that they learned the priors and combined prior and likelihood information to infer target locations in a Bayes-fashion. We then introduced a transfer condition presenting a trained prior and a likelihood that have never been put together during training. How well participants integrate this novel likelihood with their learned prior is an indicator of whether participants perform Bayesian computations. In one study, participants experienced the newly introduced likelihood, which was paired with a different prior, during training. Participants changed likelihood weighting following expected directions although the degrees of change were significantly lower than Bayes-optimal predictions. In another group, the novel likelihoods were never used during training. We found people integrated a new likelihood within (interpolation) better than the one outside (extrapolation) the range of their previous learning experience and were quantitatively Bayes-suboptimal. We replicated the findings of both studies in a validation dataset. Our results showed that Bayesian behaviours may not always be achieved by a full Bayesian computation. Future studies can apply our approach in different tasks to enhance the understanding of decision-making mechanisms.

Bio: Sophie is a postdoctoral researcher in Marta Garrido's Cognitive Neuroscience and Computational Neuropsychiatry Lab at the University of Melbourne, developing the first wearable magnetoencephalography (MEG) in Australia and investigating decision-making using the Bayesian framework. Previously, she worked as a research fellow in 2017-2019, under the supervision of Chris Miall (University of Birmingham) and Gareth Barnes (University College London), applying wearable MEG to investigate learning signals in the human cerebellum. She did her PhD in computational neuroscience at Imperial College London. Supervised by Aldo Faisal, she used Bayesian decision theory and psychophysics to relate increased sensorimotor uncertainty to a higher risk of fall incidents in older people. Not by coincidence, she is also a neurologist trained in Taiwan.

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Abstract: Background: Blindsight refers to the uncanny ability of cortically blind patients to respond correctly, or above chance level, to visual stimuli, despite having lesions in the primary visual cortex. Affective blindsight more specifically refers to the ability of correctly identifying emotional expressions presented to the patients' blind fields. This suggests that there may be alternate pathways for visual information processing in the brain, which can bypass the primary visual cortex and reach other areas that are involved in visual perception. One theory of affective blindsight posits that the amygdala, plays a key role in this phenomenon while another theory proposes that the phenomenon of affective blindsight can be explained by functional integrity of the extra-striate visual areas, via the projections from the superior colliculus and pulvinar. The posterior superior temporal sulcus (pSTS) is an extrastiate brain region that is involved in the processing of social and emotional information, such as facial expressions, gestures, and body language. Current research suggests that the pSTS may play a role in affective blindsight. However, there is limited literate on this. We report a rare case of affective blindsight for in whom we demonstrate a preserved pSTS with evidence for connectivity to pulvinar that bypass the primary visual cortex. Methods: A 58 year old man developed sudden onset of seeing flashes of light across his entire visual filed that lasted for a few seconds. This was immediately followed by complete blackness and loss of vision. He presented to us 6months later with persistent visual loss. Based clinical evaluation and structural MRI he was found to have bilateral occipital lobe infarcts involving the primary visual cortices. On testing vision, he had no phenomenological vision in the central field but had a peripherally located island of vision in the right inferior visual field. Psychophysical testing, lesion mapping, lesion network mapping and resting state fMRI, were performed. The patient's structural MRI was spatially normalized to the MNI space, and the lesion location was manually mapped. We then used resting-state functional connectivity from a healthy cohort to identify the network of regions functionally connected to the lesion site. For this the lesion map was used as seed in a resting state functional connectivity analysis and a statistically thresholded map was defined as the lesion network. Results: Psychophysical testing revealed objective evidence of blindsight for color and facial expression recognition based on the 2-alternate forced choice paradigm. Lesion mapping showed that the lesion involved the region of the occipital face area(OFA). Lesion network mapping shows that the lesion network extended additionally to involve the fusiform face area(FFA) but spared the pSTS . Functional conncectivity analysis showed intact direct connectivity of the pulvinar nuclei to the pSTS without involving the lesioned lateral geniculate body to visual cortex pathway. There was no significant functional connectivity between the amygdala and pSTS. Conclusions: In conclusion, our study adds to the literature of affective blindsight by demonstrating a role for the pSTS and its connections to the subcortical pathways via the pulvinar. As there is strong evidence for the pSTS in processing facial expressions, its preservation and its intact connections to the pulvinar are likely to be critical in the development of affective blindsight. The preserved island of vision were peripherally located in the visual field and are therefore unlikely to contribute to affective blindsight in our patient as the stimuli was presented in the central and blind fields. We did not find any significant connections between the amygdala and the pSTS in our study to support the amygdala theory of affective blindsight. We also show that connections from primary visual cortex to OFA and FFA are not necessary for affective blind sight.

Bio: Dr A.T. Prabhakar is a neurologist who is currently a professor of neurology in the department of neurological sciences, Christian medical college (CMC) Vellore.  He obtained his undergraduate and post graduate medical training from CMC Vellore. He joined as faculty in 2013 after completing his D.M in clinical neurology at CMC, Vellore. He was a visiting professor at the Montreal neurological institute Canada in 2017 and trained in lesion-symptom mapping. His areas of interest include clinical phenomenology, cognitive Neuroscience, Lesion based studies in cognitive  neuroscience,  CNS inflammatory disorders,  visual neuroscience, Consciousness studies, neuro-philosophy and Critical Care.

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Abstract: The use of technologies such as social media and video games has reshaped human perceptions, actions, and environments and has been associated with a myriad of benefits for individuals. Nevertheless, it started revealing several “dark sides” with adverse consequences. In this talk, Prof Ofir Turel will present findings from multiple studies conducted over the last 8 years, attempting to uncover the neural and psychological-behavioral underpinnings of problematic social media behaviors. Such problematic behaviors include excessive use (sometimes called “addiction”), and other unsafe and risky online behaviors (e.g., sexting, revealing private information online, taking selfies in dangerous places, and using social media while driving). He also discusses the emergent picture, as well as several open research questions.

Bio: Ofir Turel is Professor of Information Systems Management within the School of Computing and Information Systems at The University of Melbourne. He is also a Scholar in Residence at the Decision Neuroscience Program, University of Southern California. His research interests include a broad range of behavioral-psychological, managerial, and bio-physiological issues related to the use and management of computer information systems and technologies. He has published papers in top business outlets, as well as in leading psychology, psychiatry and neuroscience journals. Example psychiatry and neuroscience outlets include Journal of Psychiatric Research, Cognitive Affective & Behavioral Neuroscience, Social Neuroscience, Behavioural Brain Research, Brain Imaging and Behavior, Neuroscience Letters, Progress in Neuropsychopharmacology & Biological Psychiatry, Psychiatry Research, Biological Psychiatry, and Addiction Biology.

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Abstract: We use quantities in everyday life to guide our decisions: we judge the size and number of vegetables at the market; we dance following the tempo of music; we compare how many steps we need to reach our daily goal. How are we able to flexibly interact with such different quantities in our environment? Ultra-high resolution (7 Tesla) fMRI combined with population receptive field modelling has revealed a widespread network of brain areas that selectively process quantities, such as numerosity (object number) and object size, which are organised as topographic maps. These maps are distinct but overlap with visual field maps representing orientation and eccentricity. In this talk, I will discuss four of my recent projects that extend this line of work and illustrate (1) a network of topographic maps in association cortex that hierarchically transforms visual timing-selective responses, (2) local image contrast representations in early visual cortex are transformed into location-independent numerosity tuning in extrastriate cortex, (3) a similar derivation follows for visual timing-tuned neural responses from early visual stimulus representations, and (4) the extent of overlap and topographic direction between maps for numerosity and visual event timing supports the view of a supramodal functional network for cognitive quantities that facilitates cross-modal interactions. I will conclude by considering the implications of a supramodal functional network for learning to map quantities to symbols.

Bio: Dr Jacob Paul is a cognitive neuroscientist at the Melbourne School of Psychological Sciences. His interests include visual perception, numerical cognition, and the neurocognitive development of maths reasoning. His research spans multiple levels of explanation from modelling longitudinal patterns of maths learning, to characterising individual differences in numerical decision making, and mapping the organisation of neural circuits underlying transformations of visual quantities. He has recently returned to Melbourne after postdoctoral work in the Utrecht (Netherlands) combining ultra-high resolution 7T fMRI and computational modelling to characterise how the brain encodes basic quantities like number and time. He is passionate about translating his research findings to help enhance functional numeracy levels in the population, improve learning and instruction of mathematics, as well as constructing brain-based interventions and remediation programs for individuals with maths learning difficulties.

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Abstract: We present a descriptive model of choice with normative foundations based on how the brain is thought to represent value. An individual’s behavior is fully described by two primitives: an individual’s expectation and one free parameter we call “predisposition’. The model captures the same apparent preference phenomena illustrated by Prospect Theory but unlike Prospect Theory accounts for individual heterogeneity in parameters, employs far fewer parameters than full prospect theory, and retains neurobiological plausibility as a causal model of the choice process. Additionally, our theory makes a series of novel predictions amenable to future testing and includes an alternative explanation for endowment effect.

Bio: Prof Tymula (University of Sydney) combines theory and methodology from economics, psychology, and neuroscience to understand how people decide, why they make wrong decisions, and how to make them better choosers. Her research focused on how economic preferences change over the lifespan and contexts, including how thirst, being observed, outdoor luminance, as well as the structure of current and past choice sets affect behaviour. Prof. Tymula has been awarded over $33 million in grants as a Chief Investigator, including ARC Centre of Excellence, DECRA, Discovery, and Linkage grants. In 2017 she received the Award from the Society for Neuroeconomics for her contributions to our understanding of decision-making. She is a board member of the Society for Neuroeconomics and Executive Committee Member of the Economic Science Association.

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Abstract: The human brain must integrate information across the two hemispheres of the brain to construct a coherent representation of the perceptual world. Characterising how visual information from the left and right visual fields is represented in the two hemispheres (ipsilateral/ contralateral) over time can be the missing piece in understanding how information is transferred between hemispheres. In this talk, I will discuss how we can use electroencephalography and computational methods to investigate information processing within and across the hemispheres. I will present results that provide new insights into the dynamics of object perception and the competitive versus cooperative nature of hemispheric processing.

Bio: Dr Amanda Robinson is an ARC DECRA Fellow at the University of Sydney with expertise in perception and attention, specifically relating to object perception. She received her PhD from the Queensland Brain Institute at The University of Queensland for research on olfactory-visual integration. After a postdoc with Prof Marlene Behrmann at Carnegie Mellon University, Dr Robinson returned to Australia to join the Sydney Computational Cognitive Neuroscience Lab. Dr Robinson uses EEG, MEG and fMRI with computational methods to uncover the spatiotemporal dynamics of perceptual processing.

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Abstract

Individual differences in almost all complex traits arise from processes involving both genes (G) and the environment (E). To analyze and deepen our understanding of such GE interplay is one of the major challenges at the research frontier today and essential if we wish to identify environmental factors that have true causal effects on complex traits. In this talk, I will provide some examples from my work on expertise and skill acquisition using music as a model behavior, highlighting how we can apply methods using large scale twin and genetically informative data to disentangle GE interplay and strengthen causal inferences.

Speaker Bio

Miriam A. Mosing is a Senior Researcher and DRM Fellow at the Melbourne School of Psychological Science, and an Associate Professor at the Department of Medical Epidemiology and Biostatistics at the Karolinska Institute in Stockholm, Sweden. Her lab investigates (1) expertise development and (2) quality of life throughout lifetime and in the aged, using interdisciplinary approaches to quantify the interplay between genes and the environment. She is involved in a range of international consortia exploring genetic factors underlying complex traits, including the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium, The Loneliness Consortium (TLC), GENEtic research into Quality Of Life (GENEQOL), and the Musicality Genomics Consortium (MusicGenes) among others. Her research is currently funded by a NIH RO1 and a Wallenberg grant to explore gene-environment interplay underlying SES health gradients in late life and health effects of active engagement in culture, respectively.

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Abstract

To navigate the world safely, it is critical that we are able to rapidly evaluate and change our mind about our perceptual decisions. For example, imagine being unable to overrule a decision to cross the street when you realise a speeding car is approaching. In situations such as this, even small delays in the time it takes for you to change your mind can have serious consequences. In this talk, PhD Student, William Turner, presents findings from three studies which examined the cognitive processes underlying changes of mind (Studies 1-2) and retrospective evaluations of decision confidence (Study 3). Study 1 found that the likelihood and speed of decision reversals depends on both relative and absolute sources of sensory information, while Study 2 found that even the very earliest sensory information one receives influences later change-of-mind decisions. These results challenge existing computational models of the processes underlying changes of mind. Will presents new variants of these models which better account for these findings, and outline ways in which their assumptions can be tested further. Finally, Study 3 shows that information which is seemingly extraneous to a perceptual decision—specifically the amount of effort invested into reporting a decision outcome—nevertheless influences retrospective judgements of decision confidence. This suggests that humans are sensitive to a ‘motoric sunk cost effect’ whereby forgone physical effort expenditure can inflate decision confidence.

Speaker Bio

William Turner is a PhD candidate in the Melbourne School of Psychological Sciences. He is interested in the cognitive and neural processes underlying perceptual decisions and decision reversals.

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Abstract

Humans routinely learn the value of actions by assessing their outcomes. Critically, actions also require effort. While effort is known to affect the valuation of rewards, how effort modulates reward-based learning remains unclear. Here, we applied a reinforcement learning paradigm in which individuals (N = 213) had to exert predefined levels of force to register their responses. Our key finding was that greater exertion of effort boosts teaching signals that are positive, but blunts those that are negative. Moreover, the extent to which effort reinforced learning for a given individual was proportional to their aversion to effort. This suggests that the same computation that discounts value before choice serves to reinforce learning after that choice is made. Overall, our findings are consistent with growing evidence that motivation and learning operate within a common computational framework, and refine current reinforcement learning models.

Speaker Bio

Huw Jarvis is a PhD student in the Cognitive Neurology Lab at the Turner Institute for Brain and Mental Health at Monash University. Prior to his PhD, he completed studies in medical science (University of Tasmania) and public health (University of Melbourne), and worked in research translation at the National Health and Medical Research Council. Huw is undertaking a PhD to investigate the computational underpinnings of motivation and reward-based learning, with a view to better understanding related impairments in neurological and psychiatric disease. He was recently awarded a Fulbright Future Scholarship to pursue related work at Yale University.

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