Phenotyping Affective Symptoms of Epilepsy (PhASE Study)

Affective disorders, such as depression, psychosis and cognitive dysfunction, are a common comorbidity in epilepsy, with around 50% of Australians with epilepsy suffering from a comorbid affective disorder, compared to 17% without epilepsy. Recent discoveries in the molecular genetics of the epilepsies offer a new opportunity to understand the biological basis of comorbid neurobehavioral disorders, with this project aiming to address the question of shared genetic underpinnings for neurobehavioural disorder and epilepsy by using special genetic populations to precisely phenotype behavioural patterns in people with known epilepsy gene mutations as well as sporadic cases.


Enquiries: Dr Genevieve Rayner (


See all current projects