Pain and Cognition Neuroimaging Lab

Research Overview

We study how pain affects cognition and how cognition shapes pain perception. For example, we are interested in understanding how placebo and nocebo effects emerge, how sensory words are learned, how pain perception is modulated by social observation.

Understanding sensory perception can shed light on the neurobiology of complex cognitive processes. Unveiling the relationship between pain and cognition can be relevant for understanding not only chronic pain conditions but also psychiatric and neurological disorders, such as depression and stroke, ultimately informing diagnosis and treatment.


  • Natalia Egorova


  • Sophia Hodgson
  • Abigail Lim
  • Ayshin Rasi
  • Georgia Cotter
  • Carmen Zheng
  • Sarah Van Drunen

Research Publications


  • Gottlieb E., Churchward T., Werden E., Churilov L., Pase M., Egorova N., Howard M., Brodtmann A. Sleep-Wake Parameters Can Be Detected in Chronic Stroke Patients Using A Multi-Sensor Accelerometer: A Validation Study. Journal of Clinical Sleep Medicine (Accepted 2020).


  • Veldsman M., Werden E., Egorova N., Khlif M.S., Brodtmann A. Microstructural degeneration underlies executive dysfunction after stroke. Medrxiv* (2020) Pre-print*.
  • Brodtmann A., Khlif M.S., Egorova N., Veldsman M., Bird L., Werden E. Dynamic regional brain atrophy rates in the first year after ischemic stroke. Stroke (2020).
  • Egorova N., Dhollander T., Khlif M.S., Khan W., Werden E., Brodtmann A. Pervasive white matter fibre degeneration in ischaemic stroke. Stroke 51:1507–1513.
  • Khan W., Egorova N., Khlif M.S., Mito R., Dhollander T., Brodtmann A. Three-tissue compositional analysis reveals in-vivo microstructural heterogeneity of white matter hyperintensities following stroke. Neuroimage Apr 22:116869 .
  • Gottlieb E., Egorova N., Khlif M, Khan W., Werden E., Pase M., Howard M., Brodtmann A. Regional neurodegeneration correlates with sleep-wake dysfunction after stroke. Sleep, Mar 28. pii: zsaa054.
  • Egorova N., Benedetti F., Gollub R.L., Kong J. Between placebo and nocebo: response to control treatment is mediated by amygdala activity and connectivity. European Journal of Pain, 24:3, 580-592.


  • Egorova N., Liem F., Hachinski V., Brodtmann A. Predicted brain age after stroke. Frontiers in Aging Neuroscience, , 11:348.
  • Khlif MS., Werden E., Egorova N., Bocardi M.,Redolfi A., Bird L., Brodtmann A. Assessment of longitudinal hippocampal atrophy in the first year after ischemic stroke using automatic segmentation. Neuroimage: Clinical,  2019, 24:102008.
  • Padmanabhan J.L., Cooke D., Joutsa J., Siddiqi S.H., Ferguson M., Darby R.R., Soussand L., Horn A., Kim N.Y., Voss J.L., Naidech A.M., Brodtmann A., Egorova N., Gozzi S., Phan T.G., Corbetta M., Grafman J., Fox M.D. A human depression circuit derived from focal brain lesions. Biological Psychiatry, 2019, 86:10, 749-758.
  • Werden E., Khlif M.S., Bird L.J., Cumming T., Bradshaw J., Khan W., Pase M., Restrepo C., Veldsman M., Egorova N., Patel S.K., Gottlieb E., Brodtmann A. APOE e4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke. Journal of Alzheimer’s Disease, 2019, 71(1), 245-259.
  • Egorova N., Gottlieb E., Khlif M.S., Spratt N., Brodtmann A. Choroid plexus volume after stroke. International Journal of Stroke, 2019, 17:1747493019851277.
  • Khlif MS., Egorova N., Werden E., Redolfi A., Bocardi M., DeCarli CS., Fletcher E, Singh B., Li Q., Bird L., Brodtmann A. A comparison of automated segmentation and manual tracing in estimating hippocampal volume in ischemic stroke and healthy control participants. Neuroimage: Clinical, 2019, 21, 101581.
  • Tu Y., Park J., Ahlfors S.P., Khan S., Egorova N., Lang C., Cao J., Kong J. A neural mechanism of direct and observational conditioning for placebo and nocebo responses. Neuroimage, 2019, 184, 954-963.


  • Brodtmann A., Egorova N. The evaluation of pain in the aphasic patient. Neurology, 2018, 91:9, 377-378.
  • Egorova N., Cumming T., Shirbin C., Veldsman M., Werden E., Brodtmann A. Lower cognitive control network connectivity in stroke participants with depressive features. Translational Psychiatry, 2018, 7.
  • Hervais-Adelman A., Egorova N. , Golestani N. Beyond Bilingualism: multilingual experience correlates with caudate volume. Brain Structure and Function, 2018, 223:7, 3495–3502.

Research Projects

This Research Group doesn't currently have any projects

Faculty Research Themes


Key Contact

For further information about this research, please contact Director Natalia Egorova

Department / Centre

Melbourne School of Psychological Sciences

Unit / Centre

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