Pain and Cognition Neuroimaging Lab
-
Natalia Egorovanatalia.egorova@unimelb.edu.au
03 9035 7053
Research Overview
We study how pain affects cognition and how cognition shapes pain perception. For example, we are interested in understanding how placebo and nocebo effects emerge, how sensory words are learned, how pain perception is modulated by social observation.
Understanding sensory perception can shed light on the neurobiology of complex cognitive processes. Unveiling the relationship between pain and cognition can be relevant for understanding not only chronic pain conditions but also psychiatric and neurological disorders, such as depression and stroke, ultimately informing diagnosis and treatment.
Events
Experimental Pain Journal Club
Previous sessions:
Session 1: Pain & Sleep. Hosts: Dr. Natalia Egorova and Prof. Amy Jordan. 07/10/2020. We discussed the relationship between acute pain and sleep. We first talked about a paper on the effect of sleep fragmentation on pain sensitivity, followed by a discussion of possible novel interdisciplinary projects we can undertake at MSPS.
Session 2: Pain & Music. Hosts: Dr. Natalia Egorova, Dr. Jeanette Tamplin, Prof. Kat McFerran. 04/11/2020. We discussed the relationship between pain and music. We first presented a review paper on how music relieves pain, and then had a general discussion of music effects on experimental, acute, and chronic pain, including efficacy of music therapy.
Session 3: Pain & Reward. Hosts: Dr. Natalia Egorova, A/Prof Stefan Bode. 09/12/2020. We discussed the relationship between pain and reward. We first presented a paper on how humans integrate the prospects of pain and reward during choice, and then had a general discussion of the effects of pain on reward and information seeking.
The pdf of all discussed papers can be found: https://cloudstor.aarnet.edu.au/plus/s/VlIv9yFLK9I39m3
This series is supported by the ReWire ECR Award to Natalia Egorova.
News
Dr. Natalia Egorova together with colleagues from the Centre for Health, Exercise and Sports Medicine Dr. Michelle Hall and Dr. Fiona Dobson received 2020 MDHS Mid-Career Seeding Ideas Grant to investigate the neurobiology of hip osteoarthritis and the effect of exercise on the brain.
Ayshin Rasi presented at the Australasian Human Development Association (AHDA) Online Conference. “From "Ouchie" to "Hurt": A Cross-Linguistic Examination of Children's Pain Words”, October 22nd 2020.
Dr. Natalia Egorova presented at the Expectation, Perception and Cognition 2020 online conference. “Learning Pain Words”, October 1st 2020.
Carmen Zheng gave a talk on “The neural correlates of comorbid pain and depression” at the APS event - CCN Postgraduate Research Symposium, September 8th 2020.
Staff
- Natalia Egorova
Current students and Staff
- Mackenzie Murphy (Research Assistant)
- Mazyar Goodarz (Honours)
- Carmen Zheng (Master's)
- Sarah Van Drunen (Master's)
- Xiaoyu Sun (Master's, co-supervised with A/Prof Stefan Bode)
- Jamie Topcu (Student volunteer, co-supervised with Prof. Amy Jordan)
Past students
- Sophia Hodgson (Honours)
- Abigail Lim (Honours)
- Ayshin Rasi (Honours)
- Georgia Cotter (Honours)
- Elie Gottlieb (PhD)
Research Publications
Latest pre-prints
Liew, S.-L., Zavaliangos-Petropulu, A., Schweighofer, N., Jahanshad, N., Lang, C. E., Lohse, K. R., Banaj, N., Barisano, G., Baugh, L. A., Bhattacharya, A. K., Bigjahan, B., Borich, M. R., Boyd, L. A., Brodtmann, A., Buetefisch, C. M., Byblow, W. D., Cassidy, J. M., Ciullo, V., Conforto, A. B., Craddock, R. C., Dula, A. N., Egorova, N., Feng, W., Fercho, K. A., Gregory, C. M., Hanlon, C. A., Hayward, K. S., Holguin, J. A., Hordacre, B., Hwang, D. H., Kautz, S. A., Khlif, M. S., Kim, B., Kim, H., Kuceyeski, A., Lin, D., Liu, J., Lotze, M., MacIntosh, B. J., Margetis, J. L., Mohamed, F. B., Nordvik, J. E., Petoe, M. A., Piras, F., Raju, S., Ramos-Murguialday, A., Revill, K. P., Roberts, P., Robertson, A. D., Schambra, H. M., Seo, N. J., Shiroishi, M. S., Soekadar, S. R., Spalletta, G., Stinear, C. M., Suri, A., Tang, W. K., Thielman, G. T., Thijs, V. N., Vecchio, D., Wang, J., Ward, N. S., Westlye, L. T., Winstein, C. J., Wittenberg, G. F., Wong, K. A., Yu, C., Wolf, S. L., Cramer, S. C., & Thompson, P. M. Non-lesioned subcortical brain volumes are associated with post-stroke sensorimotor behavior across 28 cohorts worldwide: An ENIGMA Stroke Recovery analysis. bioRxiv (2020). https://doi.org/10.1101/2020.11.04.366856
Dhollander, T., Clemente, A., Singh, M., Boonstra, F., Civier, O., Juan F. D. D., Egorova N., Enticott P., Fuelscher I., Gajamange S., Genc S., Gottlieb E., Hyde C., Imms P., Kelly C., Kirkovski M., Kolbe S., Liang X., Malhotra A., Mito R., Poudel G., Silk T.J., Vaughan D.N., Zanin J., Raffelt D., Caeyenberghs, K. Fixel-based Analysis of Diffusion MRI: Methods, Applications, Challenges and Opportunities. (2020). osf.io/zu8fv
2020
- Veldsman M., Werden E., Egorova N., Khlif M.S., Brodtmann A. Microstructural degeneration underlies executive dysfunction after stroke. Scientific Reports (2020).
- Gottlieb E., Churchward T., Werden E., Churilov L., Pase M., Egorova N., Howard M., Brodtmann A. Sleep-Wake Parameters Can Be Detected in Chronic Stroke Patients Using A Multi-Sensor Accelerometer: A Validation Study. Journal of Clinical Sleep Medicine (2020).
- Brodtmann A., Khlif M.S., Egorova N., Veldsman M., Bird L., Werden E. Dynamic regional brain atrophy rates in the first year after ischemic stroke. Stroke (2020). https://doi.org/10.1161/STROKEAHA.120.030256.
- Egorova N., Dhollander T., Khlif M.S., Khan W., Werden E., Brodtmann A. Pervasive white matter fibre degeneration in ischaemic stroke. Stroke 51:1507–1513.
- Khan W., Egorova N., Khlif M.S., Mito R., Dhollander T., Brodtmann A. Three-tissue compositional analysis reveals in-vivo microstructural heterogeneity of white matter hyperintensities following stroke. Neuroimage Apr 22:116869 .
- Gottlieb E., Egorova N., Khlif M, Khan W., Werden E., Pase M., Howard M., Brodtmann A. Regional neurodegeneration correlates with sleep-wake dysfunction after stroke. Sleep, Mar 28. pii: zsaa054.
- Egorova N., Benedetti F., Gollub R.L., Kong J. Between placebo and nocebo: response to control treatment is mediated by amygdala activity and connectivity. European Journal of Pain, 24:3, 580-592.
2019
- Egorova N., Liem F., Hachinski V., Brodtmann A. Predicted brain age after stroke. Frontiers in Aging Neuroscience, , 11:348.
- Khlif MS., Werden E., Egorova N., Bocardi M.,Redolfi A., Bird L., Brodtmann A. Assessment of longitudinal hippocampal atrophy in the first year after ischemic stroke using automatic segmentation. Neuroimage: Clinical, 2019, 24:102008.
- Padmanabhan J.L., Cooke D., Joutsa J., Siddiqi S.H., Ferguson M., Darby R.R., Soussand L., Horn A., Kim N.Y., Voss J.L., Naidech A.M., Brodtmann A., Egorova N., Gozzi S., Phan T.G., Corbetta M., Grafman J., Fox M.D. A human depression circuit derived from focal brain lesions. Biological Psychiatry, 2019, 86:10, 749-758.
- Werden E., Khlif M.S., Bird L.J., Cumming T., Bradshaw J., Khan W., Pase M., Restrepo C., Veldsman M., Egorova N., Patel S.K., Gottlieb E., Brodtmann A. APOE e4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke. Journal of Alzheimer’s Disease, 2019, 71(1), 245-259.
- Egorova N., Gottlieb E., Khlif M.S., Spratt N., Brodtmann A. Choroid plexus volume after stroke. International Journal of Stroke, 2019, 17:1747493019851277.
- Khlif MS., Egorova N., Werden E., Redolfi A., Bocardi M., DeCarli CS., Fletcher E, Singh B., Li Q., Bird L., Brodtmann A. A comparison of automated segmentation and manual tracing in estimating hippocampal volume in ischemic stroke and healthy control participants. Neuroimage: Clinical, 2019, 21, 101581.
- Tu Y., Park J., Ahlfors S.P., Khan S., Egorova N., Lang C., Cao J., Kong J. A neural mechanism of direct and observational conditioning for placebo and nocebo responses. Neuroimage, 2019, 184, 954-963.
2018
- Brodtmann A., Egorova N. The evaluation of pain in the aphasic patient. Neurology, 2018, 91:9, 377-378.
- Egorova N., Cumming T., Shirbin C., Veldsman M., Werden E., Brodtmann A. Lower cognitive control network connectivity in stroke participants with depressive features. Translational Psychiatry, 2018, 7.
- Hervais-Adelman A., Egorova N. , Golestani N. Beyond Bilingualism: multilingual experience correlates with caudate volume. Brain Structure and Function, 2018, 223:7, 3495–3502.
Research Projects
This Research Group doesn't currently have any projects
Faculty Research Themes
Key Contact
For further information about this research, please contact Director Natalia Egorova
Department / Centre
Melbourne School of Psychological Sciences
Unit / Centre
MDHS Research library
Explore by researcher, school, project or topic.